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Our lab works at the interface between physics, nanotechnology, and biology.

  • we build cutting-edge biophysical tools to boost advances in biology and to gain fresh sights of the nature;
  • and we observe biology and nature to inspire new physics and to apply physics in novel ways.

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We combine quantitative super-resolved fluorescence microscopy (the technique winning the 2014 Nobel Prize in Chemistry »), single-molecule nanometric techniques and statistical physics/modeling to study biological systems at various scales, ranging from individual biological macromolecules (proteins, DNA, RNA) to individual cells/bacteria. We aim to understand quantitatively the fundamental physics that controls the central processes that remain unknown/unclear. More specifically,

    • We study the dynamics of plasmids in bacteria to understand their antibiotic resistance and to improve global health.
    • We investigate how E. coli bacteria (naturally existing in human guts) respond to different conditions to understand how life adapts to various environments.
    • We probe internal motions inside individual biological molecules to understand how nature devises and engineers these molecular machines.
    • We engineer biological macromolecules in a different way than nature does and control their functions through physics (i.e. forces).
      … read more about the Science in our lab …

 

Funding

The research in our lab has been supported by the following funding agencies.

HFSP    NSF